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Article Reference: ETtoday新聞雲 https://www.ettoday.net/news/20181107/1299833.htm
Pubilshed Date of Article: 7th November 2018
伊札基是英國曼徹斯特大學（University of Manchester）分子神經生物學榮譽退休教授。她在學術討論網站The Conversation以「疱疹導致阿茲海默症：證據越來越充足」（Alzheimer’s disease: mounting evidence that herpes virus is a cause）為標題指出，1991年發現，許多老年人的大腦中也有HSV1病毒，1997年又證實，腦中存在APOE4基因的人，罹患阿茲海默症的風險相當高。
Translation of Article (Edited):
According to the latest research, more evidences have shown that herpes may cause Alzheimer. Ruth Itzhaki, the British molecular neurobiologist, wrote an article to point it out. “I have found the most powerful evidence showing that herpes virus is one of the causes of Alzheimer. Therefore, safe and effective antiviral drugs may cure this disease, and children can even prevent Alzheimer by vaccination.” Itzhaki has mentioned, “The most exciting thing is that, Taiwan has already carried out a large scale of sample experiment, proving that applying specific anti-herpes drugs is effective for preventing Alzheimer. We really hope the other countries that are also having researches on anti-herpes drugs would show the same result.”
According to BBC, Alzheimer’s Disease is one of the most common dementia, with over thirty million people diagnosed with Alzheimer’s Disease worldwide. Nowadays, Alzheimer’s Disease could only be remitted by drugs and cannot be completely cured. Itzhaki indicated that Herpes Simplex Virus 1 (HSV1) is the major cause of Alzheimer’s Disease. Most people get infected by the HSV1 during infancy, while the virus will enter human’s brain when a person is aging or getting a immune system deficiency. HSV1 is latent in the human peripheral neural system. The virus may activate when people are under huge stress, having weak immune system or brain inflammation by microorganisms, and would possibly reactivate repeatedly, causing accumulative damage in the brain.
Ruth Itzhaki, the professor emeritus of molecular neurobiology at the University of Manchester, published the article “Alzheimer’s disease: mounting evidence that herpes virus is a cause” in The Conversation. The article suggested that herpes simplex virus type 1 (HSV1) were discovered in many elders in 1991. In 1997, they also discovered that people who had APOE4 gene tend to have higher risk in getting Alzheimer’s disease.
The activation of the virus causes direct damage to the infected cells, and may induce inflammation. The cumulative damage caused by repeat activation might lead to Alzheimer’s disease for those who carried APOE4 gene. “Researches have shown the association between herpes virus and Alzheimer’s disease, but it still could not prove that the virus was the actual cause.” The only way to prove that whether microbes are the pathogenesis or not is to treat the microbe targets with specific antimicrobial agents or specific vaccines, then follow to see whether the occurrence rate of the diseases is reduced.